he was born the son of alexander and anna (holmes) mcguffey near claysville in washington county, pennsylvania, which is 45 miles southwest of pittsburgh. in 1802 the mcguffey family moved further out into the frontier at tuscarawas county, ohio. he attended country school, and after receiving special instruction at youngstown, he attended greersburg academy in darlington, pennsylvania. afterwards, he attended and graduated from pennsylvania's washington college, where he became an instructor.
he was close friends with washington college's president andrew wylie and lived in wylie's house for a time; they often would walk the 3 miles to washington college together.
mcguffey's house in oxfordmcguffey left washington college in 1826 to become a professor at miami university in oxford, ohio. a year later in 1827, he was married to harriet spinning of dayton, ohio, with whom he had five children. in 1829, he was ordained at bethel chapel as a minister in the presbyterian church. it was in oxford that he created the most important contribution of his life: the mcguffey readers. his books sold over 122 million copies. he was very fond of teaching and children as he geared the books toward a younger audience.
in 1836, he left miami to become president of cincinnati college, where he also served as a distinguished teacher and lecturer. he left cincinnati in 1839 to become the 4th president of ohio university, which he left in 1843 to become president of woodward college (really a secondary school) in cincinnati.

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